Plant Extracts
➢ Product Name: St. John’s Wort Extract
➢ Latin Name: Hypericum perforatum L.
➢ Plant Part Used: Dried aerial herb of Guttiferae Hypericum perforatum (flower-stage aerial parts)
Manufactured from dried aerial parts of flowering Hypericum perforatum via sorting-impurity removal, ethanol-water composite extraction, macroporous-resin enrichment and purification, vacuum concentration and aseptic spray-drying. The product retains natural active components of St. John’s wort, mainly including hypericin, pseudohypericin, hyperforin and flavonoids. No artificial monomer blending or extra exogenous auxiliary materials are added. It delivers anti-oxidation and anti-inflammatory activities, and is a widely-used botanical raw material in overseas dietary-supplement markets. Compared with ordinary herbal crude powder, enriched extract features controllable concentrations of active ingredients and multi-component synergism, suitable for development of dietary-supplement products for mood-soothing purposes.
➢ Raw Material Source: 100% extracted from aerial parts of Hypericum perforatum, free of starch, dextrin and other exogenous additives.
➢ Processing Grade: Low-temperature first-grade refined extract. High-temperature-caused degradation of hypericin-type components is avoided; no artificial blending. Impurities, solvent residues, heavy metals and pesticide residues are strictly controlled to meet raw-material limit requirements.
➢ Core Indicators: Total hypericin (HPLC) 0.3%-3.0%, hyperforin 2%-5%, total flavonoids 5%-20%; multiple customized grades are available.
➢ Physical and Chemical Properties: Brown fine powder. Hyperforin is sensitive to light and temperature. Encapsulation modification can be applied to improve stability for multiple dosage-form development.
➢ Applicable Dosage Forms: Tablets, capsules, compound powders and others.
➢ Storage Properties: Sealed, light-proof and moisture-proof. Store in cool and dry place with strict light avoidance to guarantee stability of active components.
➢ Authentic Raw Material, High-purity & High-activity:
Adopt flowering-stage aerial parts of Hypericum perforatum with strictly controlled harvesting time. Sufficient intrinsic content of hypericin and hyperforin guarantees raw-material activity foundation from the source.
➢ Low-temperature Activity Lock, Natural Components:
Mild extraction and resin-enrichment processes reduce degradation of light-sensitive active substances and preserve natural component ratio of the herb. Synergistic performance of natural compound system is superior to single monomer.
➢ Zero-adulteration Purity, Safe & Compliant:
Free of blending, fillers, pigments, flavors, preservatives and harmful auxiliaries. Residues and microorganisms are strictly controlled in compliance with USP and EP raw-material specifications.
➢ Strong Compatibility, Full-scenario Adaptation:
Mainly ethanol-soluble; modified grades show improved water-dispersibility. Usable alone or compounded with other botanical extracts. Relevant risk warnings regarding photosensitivity shall be considered in formula design.
➢ Standardized Production, Stable Batch Quality:
Produced in 100,000-class GMP workshop. Tested by HPLC and UV dual-methods. Key indicators including hypericin, hyperforin and total flavonoids are strictly controlled for uniform batch quality and full traceability.
Uniform fine powder from brown to dark brown with natural herbal color, loose, delicate and good fluidity. It bears characteristic herbal odor of St. John’s wort, free of mildewed, rancid or scorched peculiar odor. Conventional grades show limited water solubility. Encapsulated modified products improve water-dispersibility and reduce light-induced damage to active components. Overall quality is superior to simply crushed St. John’s wort herb powder.
Multi-component synergistic system composed of hyperforin, hypericin and flavonoids. Hypericin is a photosensitive substance sensitive to light and high temperature, prone to degradation under strong light exposure. Micro-capsule encapsulation mitigates photosensitivity and compensates for the defect of easy activity decay of ordinary herbal extracts.
Good formulation compatibility. High-purity grades are mainly applied in solid dosage forms such as tablets and capsules. Encapsulated modified products fit formulas requiring high stability. Photosensitivity risks shall be noted and corresponding warnings shall be marked on finished-product labels. Not recommended for liquid beverage systems. Compatible with conventional solid-dosage industrial processes to satisfy mass-production and high-end customized development.
Food-grade high-barrier light-proof packaging isolates light, oxygen and moisture to slow down oxidative degradation and moisture caking of photosensitive components. Store at cool room temperature without freezing; direct light exposure must be avoided. Use up promptly after opening. Flexible packaging specifications support lab-scale R&D, pilot test and large-scale production.
St. John’s wort active complex, mainly hyperforin, hypericin, pseudohypericin, together with flavonoids such as quercetin and rutin. Synergy of multiple components forms the material basis for anti-oxidation and anti-inflammatory modulation.
Flavonoids and hypericin-related components contain phenolic hydroxyl groups, which directly scavenge reactive-oxygen free radicals and inhibit lipid peroxidation. They up-regulate activities of endogenous antioxidant enzymes including SOD and glutathione to build anti-oxidant defense barriers and alleviate cell damage induced by oxidative stress.
Modulate NF-κB signaling pathway, down-regulate release of pro-inflammatory factors including TNF-α and IL-6, inhibit chronic low-grade inflammatory response in vivo and mitigate inflammatory damage triggered by oxidative stress.
Hyperforin modulates re-uptake of multiple neurotransmitters in vivo and exerts auxiliary effects on mood regulation, representing the core target of this raw material.
Polyphenol active components act on cell membranes, mitigate free-radical attack against membrane lipids, maintain cell-membrane integrity and reduce cell damage induced by external oxidative stimuli.
Mainly used as raw material for export-oriented dietary supplements in capsules and tablets, for consumers requiring mood soothing and anti-oxidation maintenance.
Note: St. John’s wort is not approved as ordinary food raw material in China. Domestic product development shall strictly follow local regulatory requirements.
Classic herbal raw material for European and American dietary supplements, featured with mood soothing and anti-oxidation maintenance. Developable into tablets, capsules and compound powders targeting overseas consumer markets.
Mainly adopted in solid preparations, rarely used in liquid beverages. Often compounded with valerian extract and magnesium to manufacture mood-support dietary-supplement products.
For scientific-research institutes and enterprise new-product development. Customized raw materials with varied hypericin contents and encapsulation modification are available to support high-end compound-product development for mood management and anti-oxidation purposes.
Meets quality requirements of USP and EP. Complete test documents are available for bulk export to global markets. It is one of the mainstream herbal-extract raw materials in international markets.
Regulatory and safety risks must be fully assessed before pet-formula adoption. After safety evaluation, limited addition is allowed in pet nutritional tablets for anti-oxidation related directions.
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